December 20, 2012

EMMA promises better cancer therapy

University of Oxford
Source: STFC

10 Jan 12

The EMMA particle accelerator. Photo: STFC

The first results from a new type of particle accelerator suggest how smaller, cheaper therapy machines, which could revolutionise cancer treatment, could be built.

The prototype accelerator EMMA (Electron Model for Many Applications), which was constructed at the Science and Technology Facilities Council’s (STFC) Daresbury Laboratory, was designed by an international team including Oxford University scientists.

Current accelerators – used in medicine in conventional radiation therapy and X-ray machines as well as industry and fundamental scientific research – are limited by their size, complexity and cost.

EMMA’s technology is more compact, cost effective and operationally simpler, allowing the more widespread use of accelerators to tackle some of the most difficult problems facing society. The team report in Nature Physics the first experimental results from EMMA, confirming the proof of principle underlying its technology.

It is hoped that in the future this technology will allow hospitals to implement a newer and more effective form of beam therapy to help cure some of the most difficult cancers.

Professor Ken Peach of the John Adams Institute for Accelerator Science and the Oxford Martin School’s Particle Therapy Cancer Research Institute said: ‘This is a very exciting result – it is very rare these days to discover a new principle of particle acceleration, and this could lead to the development of novel or greatly improved applications of accelerators, for example in the treatment of some forms of cancer.’

EMMA’s ground-breaking concept is based on a ring of magnets which use their combined magnetic field simultaneously to steer and focus the electron beam around the machine. The strength of this magnetic field increases steeply as the beam spirals outwards while it is accelerated to 20 million electron volts around the ring. Due to the strength of the magnetic focussing, the displacement of the beam as it accelerates and spirals around the ring is much smaller than in any equivalent accelerator. As a result, EMMA’s ring of magnets is much more compact and it is easier to accelerate the beam.

The experience gained in the development and operation of EMMA's new technology will inform the design and eventual construction of a prototype proton/carbon ion accelerator for medical applications (PAMELA).

Engineered and constructed at the Science and Technology Facilities Council’s (STFC) Daresbury Laboratory, EMMA was designed by an international consortium of scientists as part of the CONFORM project, which includes the Universities of Manchester, Oxford, Surrey, Imperial, Brunel, Liverpool and Huddersfield, STFC, the Cockcroft and John Adams Institutes, as well as a number of international partners which include the Brookhaven National Laboratory and Fermilab in the US, and TRIUMF in Canada.
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December 14, 2012

ProTom Achieves Scheduled Milestone of Beam at Gantry Room Isocenter

FLOWER MOUND, Texas & FLINT, Mich.--(BUSINESS WIRE)--

Testing of a compact cancer-treatment technology from ProTom International, Inc. (“ProTom”) demonstrated last week that the system achieves its design specification: delivering high-energy protons to isocenter at a beam intensity sufficient for standard clinical practice. The ProTom technical team measured stable and reproducible performance on the Radiance 330® Proton Therapy System at the McLaren Proton Therapy Center (“MPTC”) in Flint, Michigan.

This is the first time that ProTom has tested its compact system’s gantry beam optics design. “Measuring high beam intensities at isocenter indicates well-functioning integration among various subsystems of the Radiance 330 necessary for clinical implementation,” said Vahagn Nazaryan, Ph.D., Senior Vice President of Physics for ProTom. “We delivered beam through the gantry and nozzle in the first of three gantry treatment rooms as part of validation and verification of our technical design,” stated Dr. Nazaryan. “We are pleased that the system performed as designed and quickly achieved a dose rate sufficient for standard clinical practice.”

“We are excited by the results of successful beam transport testing through our first gantry treatment room: these results were independently reproduced by our clinical physics team,” said Sung Park, Ph.D., Chief Physicist for McLaren Cancer Institute.

Earlier in the summer, ProTom installed a new custom-designed radiofrequency quadrupole (RFQ) proton linac injector from AccSys Technology Inc. This upgrade has significantly improved accelerated proton beam intensities. The RFQ upgrade resulted in an increase in injection intensity yielding in excess of several times the number of protons per cycle accelerated in the synchrotron, with further tuning and optimization ongoing at McLaren.

“Both the ProTom and McLaren teams are to be commended for achieving this very significant result, which continues to validate that the system is performing as it was designed,” said ProTom CEO Stephen L. Spotts. “ProTom is focused on final validation and testing in order to secure all regulatory clearances necessary for clinical operation.” Spotts also noted, “It is my firm belief that our Radiance 330 system is not only the most advanced proton beam scanning system available but the most economical solution as well.“

About ProTom International, Inc.

ProTom International, Inc. is a medical device company committed to a new generation of financially viable proton radiotherapy centers that are easier to implement and equipped with advanced, compact technology. The Radiance 330 Proton therapy system makes community-based proton therapy truly accessible by reducing cost and technology barriers inherent with previous generations of equipment. To find out more about the future of proton therapy, visit us at www.protominternational.com.

About McLaren Health Care Corporation

Recognized by Verispan as one of the top Integrated Health Networks in the nation, McLaren Health Care includes more than 150 locations, 15,000 employees and over 10,000 network physicians. It includes nine wholly-owned regional hospitals: McLaren Regional Medical Center in Flint; Lapeer Regional Medical Center; Ingham Regional Medical Center and Ingham Regional Orthopedic Hospital in Lansing; Bay Regional Medical Center and Bay Special Care Hospital in Bay City; Mount Clemens Regional Medical Center in Mount Clemens; Central Michigan Community Hospital in Mt. Pleasant and POH Regional Medical Center in Pontiac. McLaren Homecare Group, an award-winning home health provider, and McLaren Health Plan, a top-rated commercial and Medicaid HMO are also a part of the system. To find out more about how we’re changing the future of health care, visit www.mclaren.org.

* The Radiance 330 Proton Therapy System has not been cleared by the U.S. Food and Drug Administration (FDA) for commercial distribution in the U.S. at this time.

Contact:
ProTom International
Stephen Sledge, 904-502-4032
ssledge@protominternational.com
or
McLaren Health Care
Kevin Tompkins, 810-342-1173
KevinTo@mclaren.org
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